Most sedating antidepressants
Below are several lists of TCAs grouped by how they function.Although some TCAs tend to affect serotonin and norepinephrine equally, some affect one to a significantly greater extent.It also is popular in the form of “Deanxit” which is a drug that combines Melitracen and Flupentixol.
Additionally there are others that don’t affect either neurotransmitter to a significant extent; these are listed as “atypical” TCAs.
Below is a list of TCAs that affect serotonin and norepinephrine to a similar extent.
It was created by Merck and approved by the FDA for medical use in 1961.
This drug works primarily as a serotonin-norepinephrine reuptake inhibitor, favoring the serotonin reuptake inhibition slightly more than that of norepinephrine.
This lead to a trend of many companies developing tricyclic antidepressants with different three ring structures from Imipramine.